There are several different components of the blood that can be transfused. Red blood cells are most commonly transfused. If your child's healthcare provider has decided your child might need a transfusion of blood, or blood products, he or she will explain the reasons for the transfusion. There are several reasons why your child may need a blood transfusion, including the following:
A sudden loss of blood because of trauma
An anticipated or actual loss of blood during surgery
A low blood count before, during, or after surgery
Severe heart, lung, liver, or kidney disease
Bone marrow failure
Moderate to severe anemia due to radiation treatments or medicine, such as chemotherapy
Human blood is made of a fluid called plasma that carries red and white blood cells and platelets. Each part of blood has special functions and can be separated from each other. The bone marrow is the soft, spongy material in the center of the bones that makes most of the body's blood cells.
Red blood cells carry oxygen from the lungs to other body organs and carry carbon dioxide back to the lungs. A certain number of these cells are needed for the body to function. Bleeding due to trauma, surgery, or disease may cause a low red blood cell count.
White blood cells fight infections by destroying bacteria, viruses, and other germs. White blood cells are rarely transfused. They are usually reserved for children who have a low white cell count and severe infection that does not respond to antibiotic therapy.
Platelets help control bleeding by making clots in the blood vessels opened by injury or surgery. The body may not be able to make enough platelets because of bone marrow disorders, increased destruction of platelets, or medicines, such as chemotherapy. Platelets may be transfused before a procedure that may cause a child with a low platelet count to bleed.
Plasma carries the blood cells throughout the body and contains proteins, vitamins, and minerals. Some of the proteins help the blood to clot. Plasma or fresh frozen plasma can be transfused in children who have a severe deficiency of certain clotting components of the blood.
The blood used at most hospitals is from volunteer donors. Donors are not paid for giving blood or blood products. Each blood donor must answer medical history questions and be given a limited physical exam before being accepted as a donor. The donated blood is carefully tested for hepatitis viruses B and C, syphilis, Chagas disease, West Nile virus, and antibodies to two immunodeficiency viruses, including HIV. These tests decrease the chances of transfusion-related infections.
Blood is collected and stored in sterile bags. The bags are used once and then thrown away. Before blood is given to your child, it is typed and cross-matched with his or her own blood to make sure it is compatible. The blood will be given through a needle or catheter placed in the vein. Your child's temperature, blood pressure, and heart rate will be checked many times while the blood is being given. It may take a few hours to complete the process.
A directed (or designated) blood donation is one in which a person donates blood that is reserved (at the time of donation) for the transfusion of a specific patient at a later date. The donor is usually a family member or a close friend that has been chosen by the patient's family. Talk with your child's healthcare provider if you are interested in learning more about directed donation. It is recommended that families donate in the child's name versus directed donation, because if directed blood is not needed, it is wasted. Blood must be donated within a month of the surgery. If not used, it will be released. An autologous donation is blood collected from the patient in advance of planned surgery.
There is no proof that directed donors are safer than volunteer donors. Not all directed donor blood will be compatible with the patient's blood.
Most transfusions are performed without any problems. Mild side effects may include symptoms of an allergic reaction such as headache, fever, itching, or rash. This type of reaction can usually be treated with medicine, should your child need additional transfusions. Serious side effects are rare and may include difficulty breathing and sudden drops in blood pressure. Transfusion reactions can happen even if the donated blood is the correct blood type. Transfusion with blood of the wrong type can be fatal, but this is unlikely to happen because all blood is checked multiple times by medical personnel.